Toluene → HCID 54196354, compound

Participants

Reaction Steps

A solution of 3,4-dihydroxy-6-chlorobenzoic acid (48 g: 250 mMol.) in a mixture of toluene (180 ml) and ethanol (180 ml) is heated under reflux under Dean Stark apparatus filled with Molecular Sieves for 12 hours. The reaction mixture is cooled and washed with aqueous sodium hydrogen carbonate and water, dried and concentrated under reduced pressure to give 6-chloro-3,4-dihydroxybenzoic acid ethyl ester (52.7 g). Yield: 95%.

Provenance & Evidence