Potassium Carbonate → HCID 54210320, compound

Participants

Reaction Steps

To a solution of 3,4-dihydroxy-6-chlorobenzoic acid ethyl ester (52.7 g: 243 mMol.) in dimethylformamide (170 ml) are added potassium carbonate (105 g; 3.1 Eq.) and p-methoxybenzyl bromide (151 g: 3.1 Eq.), and the mixture is stirred at room temperature for 4 hours. The reaction mixture is diluted with ice water and filtered to collect the resulting precipitate, which is washed with methanol and water to give 6-chloro-3,4-bis(p-methoxybenzyloxy)benzoic acid ethyl ester (110 g). Yield: 99%.

Provenance & Evidence