Hydrochloric Acid → HCID 19880183, compound

Participants

Reaction Steps

A solution of 6-chloro-3,4-bis(p-methoxybenzyloxy)benzoic acid ethyl ester (110 g: 240 mMol.) in a mixture of ethanol (800 ml), pg,64 tetrahydrofuran (150 ml), and aqueous 2N -sodium hydroxide (264 ml: 2.2 Eq.) is heated at 70° C. for 2 hours. The reaction mixture is cooled and acidified with hydrochloric acid. The resulting precipitate is collected by filtration and washed with ethanol and water to give 6-chloro-3,4-bis(p-methoxybenzyloxy)benzoic acid (94 g). Yield: 99%.

Provenance & Evidence