Dicyclohexylcarbodiimide → HCID 19880191, compound

Participants

Reaction Steps

To a solution of 2,5-dichloro-3,4-bis(p-methoxybenzyloxy)benzoic acid (2.02 g: 4.36 mMol.) and 1-hydroxybenzotriazole (648 mg: 1.1 Eq.) in tetrahydrofuran (40 ml) is added dicyclohexylcarbodiimide (990 mg: 1.1 Eq.), and the mixture is stirred at room temperature for 90 minutes. This solution is mixed with N-methylpiperazine (0.66 g: 1.5 Eq.) and stirred at room temperature for 1 hour. The reaction mixture is filtered to remove solid and concentrated under reduced pressure. The residue is purified by silica gel chromatography to give 1-(2,5-dichloro-3,4-bis(p-methoxybenzyloxy)benzoyl)-4-methylpiperazine (1.7 g) from the fraction eluting with 5% methanol-chloroform. Yield: 71%.

Provenance & Evidence