Dicyclohexylcarbodiimide → HCID 19880188, compound

Participants

Reaction Steps

A mixture of 3-methoxy-4-p-methoxybenzyloxybenzoic acid (2.88 g: 10 mMol.), 1-hydroxybenzotriazole (1.49 g: 1.1 Eq.), and dicyclohexylcarbodiimide (2.27 g: 1.1 Eq.) in tetrahydrofuran (100 ml) is kept at room temperature for 3 hours. To this solution is added N-methylpiperazine (2.22 ml: 2 Eq.), and the mixture is kept at room temperature overnight to give 1-(3-methoxy-4-p-methoxybenzyloxybenzoyl)-4-methylpiperazine (3.45 g). Yield: 93%.

Provenance & Evidence