Sodium Iodide → HCID 89495917, compound

Participants

Reaction Steps

To a solution of 7β-[2-(2-t-butoxycarbonylamino-4-thiazolyl)-2-methoxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester (652 mg: 1 mMol.) in acetone (7 ml) is added sodium iodide (450 mg: 3 Eq.), and the mixture is stirred at room temperature for 1 hour. The reaction mixture is diluted with ethyl acetate, washed with water, dried, and concentrated under reduced pressure to give 7β-[2-(2-t-butoxycarbonylamino-4-thiazolyl)-2-methoxyimino) acetamido]-3-iodomethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester (730 mg). Yield: 98%.

Provenance & Evidence