2-Fluorobenzoyl chloride → HCID 3438030, compound

HRID 1885271Notes

Reaction equation

HRID 1885271 reaction equation
[CH3:1][NH:2][C:3](=[S:6])[NH:4][NH2:5].[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10](Cl)=[O:11].Cl.N1C=CC=CC=1>N1C=CC=CC=1>[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([NH:5][NH:4][C:3]([NH:2][CH3:1])=[S:6])=[O:11]

Participants

5

Reactant 3

HCID 98082-Fluorobenzoyl chlorideHCID 2723853N-MethylhydrazinecarbothioamideHCID 10176127Pyridinium chloride

Product 1

HCID 3438030HCID 3438030, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Procedure

To a stirred room temperature solution of 4-methylthiosemicarbazide (10.5 g, 1.00×10-1 mole) and pyridine (250 ml), 2-fluorobenzoyl chloride (11.9 ml, 1.00×10-1 mole) was added dropwise. After stirring overnight at room temperature the excess pyridine was evaporated at reduced pressure first on a rotary evaporator and then at high vacuum. This afforded a mixture of the desired product and pyridine hydrochloride which is used without further purification in the subsequent cyclization step.

Workup

  1. customwas evaporated at reduced pressure first on a rotary evaporator
  2. customThis afforded

Sources & evidence

ORD record
ord-3e90fb0eb5c04c849066fb74946e93f5
Source dataset
uspto-grants-1992_09
Patent number
US05143933

Reaction notes

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