Triethylamine → HCID 178442817, compound

Participants

Reaction Steps

A mixture of methyl 2-chloro-2-(2-dodecylphenyl)acetate (0.615 g, 1.75 mmol), 5-(2-mercaptoethyl)tetrazole (0.227 g, 1.75 mmol), and triethylamine (0.48 ml, 3.5 mmol) in 20 ml of methylene chloride was stirred 18 hours at 22° and the solvent was evaporated. The residue taken up in diethyl ether, washed with 1N hydrochloric acid, dried and the solvent removed. The residue was chromatographed over a silica gel column. Impurities were eluted with ethyl acetate/hexane (1:3), and the product was eluted with methanol/ethyl acetate (1:19). Evaporation of the solvents from these functions gave the desired product, 0.570 g (73%).

Provenance & Evidence