Sodium Hydroxide → HCID 10844509, compound

Participants

Reaction Steps

To a suspension of 0.99 g of lithium aluminium hydride in 15 ml of tetrahydrofuran, a solution of 3.03 g of (2S,4R)-4-azido 2-ethoxycarbonyl-N-ethyl pyrrolidine in 10 ml of tetrahydrofuran was dropwise added while cooling and the combined was stirred for 1 hour. Sirring was continued at room temperature for additional 2 hours, and then a mixture of 4.7 ml of aqueous 1N-NaOH solution and 33 ml of tetrahydrofuran was added to decompose excess amount of lithium aluminium hydride. After filtrating the mixture to remove undissolved substance, the filtrate was concentrated under reduced pressure to obtain (2S,4R)-4-amino-N-ethyl-2-hydroxymethyl pyrrolidine as an oily product. Yield 1.33 g.

Provenance & Evidence