Dimethylformamide → HCID 22845730, compound

Participants

Reaction Steps

A mixture of 3.50 g of N-ethyl-4-mesyloxy-L-proline ethylester, 1.54 g of sodium azide and 10 ml of DMF was reacted at an inner temperature of 90° C. for 4 hours and after cooling, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was dried over magnesium sulfate and concentrated to obtain an oily product. This was purified by means of silica column chromatography to obtain 2.05 g of 4-azido-N-ethyl-L-proline ethylester.

Provenance & Evidence