Sodium Azide → HCID 10751025, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.5 g of (2S,4R)-2-ethoxycarbonyl-N-ethyl-4-methanesulfonyloxy pyrrolidine, 1.54 g of sodium azide and 10 ml of dimethylformamide was stirred at 90° C. for 4 hours. After cooling, the reaction mixture was poured into ice-water and extracted with ethyl acetate. The organic extract was washed with water, dried and concentrated under reduced pressure to obtain crude product. This was then subjected to a silica gel column chromatography (elution liq. toluene-ethyl acetate) to obtain pure (2S,4S)-4-azido-2-ethoxycarbonylN-ethyl pyrrolidine as an oily product. Yield 2.05 g.

Provenance & Evidence