Sodium Hydroxide → HCID 10701943, compound

Participants

Reaction Steps

0.41 g of lithium aluminium hydride were suspended in 10 ml of tetrahydrofuran and while cooling, a solution of 1.9 g of (2S,4S)-4-azido-2-ethoxycarbonyl-N-ethyl pyrrolidine in 4 ml of tetrahydrofuran was dropwise added thereto. After stirring at the same temperature for 1 hour, the temperature of reaction mixture was raised to room temperature and the mixture was stirred for 2 hours. To this, a mixture of 1 ml of 1N-NaOH solution and 9 ml of tetrahydrofuran was added to decompose lithium aluminium hydride and undissolved material was filtered. The filtrate was concentrated under reduced pressure to obtain (2S,4S)-4-amino-N-ethyl2-hydroxymethyl pyrrolidine. Yield 1.05 g.

Provenance & Evidence