HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-2-pyrrolidone → 6-Fluorobenzo[b]thiophen-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Methyl 3-amino-6-fluoro-1-benzothiophene-2-carboxylate | HCID 10585280 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Fluorobenzo[b]thiophen-3-amine | HCID 10797162 | 62.5% |
Reaction Conditions
| Temperature | 176 °C |
|---|
Reaction Steps
A mixture of methyl-6-fluoro-3-aminobenzo[b]thiophene-2-carboxylate (20.1 g), 1-methylpiperazine (13.1 g), and 1-methyl-2-pyrrolidinone (100 ml) was heated at 176° C. for 2 hrs, under nitrogen. The solution was diluted with water (400 ml) and extracted with ether. The combined extracts were washed with water, brine, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give 9.32 g of 3-amino-6-fluorobenzo[b]thiophene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05143923 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-3ca11fa1fc3046df8bfcfcaf20238ff6 |
| Source note | uspto-grants-1992_09 |