HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 15661455, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | HCID 15661454 | HCID 15661454 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 15661455 | HCID 15661455 | — |
Reaction Steps
3-Methoxycarbonyl-1-hydroxymethyl-9-fluorenol (0.96 g) was treated with dihydropyran (0.43 ml) and p-toluenesulfonic acid (20 mg) in CH2Cl2 (20 ml) for 0.5 hour. The reaction mixture was washed once with NaHCO3 (10% soln) then dried and evaporated to give a mixture of products. Chromatography on silica gel using EtOAc/hexane 1:1 as eluant gave the product (403 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05144028 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-7e9861a573d74a24ad8a027ced94211b |
| Source note | uspto-grants-1992_09 |