HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfide → 2-Methyl-1-phenyl-1-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfide | HCID 1068 | — |
| Reactant | Triglyme | HCID 8189 | — |
| Reactant | Ethyl sulfide | HCID 9609 | — |
| Reactant | Phenylpropanolamine Hydrochloride | HCID 62943 | — |
| Reactant | Isobutyrophenone | HCID 69144 | — |
| Reactant | (E)-1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)-4,4-dimethyl-1-penten-3-one | HCID 11110117 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 2-Methyl-1-phenyl-1-propanol | HCID 95626 | 97.2% |
Reaction Steps
The same procedure as in Example 1 was repeated except that (+)-norephedrine hydrochloride was replaced by (-)-norephedrine hydrochloride, triglyme was replaced by 0.4 ml of dimethylformamide, dimethyl sulfide was replaced by diethyl sulfide, monochlorobenzene was replaced by 1,2-dichloroethane, (E)-1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)-4,4-dimethyl-1-penten-3-one was replaced by 0.27 g (1.85 mmoles) of phenyl isopropyl ketone, and the reduction reaction was conducted for 18.5 hours, to obtain 0.27 g of crude (-)-phenylisobutyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05144039 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-ac302dae37ed47baba21ba0f22a696a4 |
| Source note | uspto-grants-1992_09 |