HCID 57125887, compound → HCID 86746116, compound
Reaction equation
[CH2:1]([CH:3]1[CH:29]=[C:28]([CH3:30])[CH2:27][CH:26]([CH3:31])[CH2:25][CH:24]([O:32][CH3:33])[CH:23]2[O:34][C:19]([OH:38])([CH:20]([CH3:37])[CH2:21][CH:22]2[O:35][CH3:36])[C:18](=[O:39])[C:17](=[O:40])[N:16]2[CH:11]([CH2:12][CH2:13][CH2:14][CH2:15]2)[C:10](=[O:41])[O:9][CH:8]([C:42]([CH3:60])=[CH:43][CH:44]2[CH2:49][CH2:48][CH:47]([O:50][CH3:51])[CH:46]([O:52][Si](C(C)(C)C)(C)C)[CH2:45]2)[CH:7]([CH3:61])[CH:6]([O:62][Si:63]([CH:70]([CH3:72])[CH3:71])([CH:67]([CH3:69])[CH3:68])[CH:64]([CH3:66])[CH3:65])[CH2:5][C:4]1=[O:73])[CH3:2]>CO>[CH2:1]([CH:3]1[CH:29]=[C:28]([CH3:30])[CH2:27][CH:26]([CH3:31])[CH2:25][CH:24]([O:32][CH3:33])[CH:23]2[O:34][C:19]([OH:38])([CH:20]([CH3:37])[CH2:21][CH:22]2[O:35][CH3:36])[C:18](=[O:39])[C:17](=[O:40])[N:16]2[CH:11]([CH2:12][CH2:13][CH2:14][CH2:15]2)[C:10](=[O:41])[O:9][CH:8]([C:42]([CH3:60])=[CH:43][CH:44]2[CH2:49][CH2:48][CH:47]([O:50][CH3:51])[CH:46]([OH:52])[CH2:45]2)[CH:7]([CH3:61])[CH:6]([O:62][Si:63]([CH:64]([CH3:66])[CH3:65])([CH:70]([CH3:72])[CH3:71])[CH:67]([CH3:69])[CH3:68])[CH2:5][C:4]1=[O:73])[CH3:2]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 17-ethyl-1-hydroxy-14-triisopropylsilyloxy-12-[2'-(3"-t-butyldimethylsilyloxy-4"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone is treated with p-toluenesulfonic in methanol as in Example 67 to yield 17-ethyl-1-hydroxy-14-triisopropylsilyloxy-12-[2'-(3"-hydroxy-4"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9] octacos-18-ene-2,3,10,16-tetraone.
Sources & evidence
- ORD record
- ord-573d6ae2f73249329af1889f40f4602e
- Source dataset
- uspto-grants-1992_09
- Patent number
- US05143918
Reaction notes
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