p-Toluenesulfonic acid → HCID 86746120, compound

Participants

Reaction Steps

To a solution of 17-ethyl-1-hydroxy-12-[2'-(3"-chloro-4"-trimethylsilyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone (20 mg) in 1 ml of methylene chloride was added a solution of p-toluenesulfonic acid (200 μl, 1% solution in methanol) and stirred for 20 minutes at room temperature. Purification of the crude product by preparative tlc on silica gel (1:1 hexane:ethyl acetate) gave the title compound in quantitative yield.

Provenance & Evidence