HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1885462Generated: October 31, 2026
1-Bromohexadecane → 2-[(Hexadecyloxy)methyl]-4-heneicosyn-1-ol
https://huagongshe.com/reaction/1885462
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromohexadecane | HCID 8213 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(2-Nonadecynyl)-1,3-propanediol | HCID 19764360 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[(Hexadecyloxy)methyl]-4-heneicosyn-1-ol | HCID 19764322 | — |
Reaction Steps
A mixture of 5.0 g of 2-(2-nonadecynyl)-1,3-propanediol, 75 ml of N,N-dimethylformamide, 710 mg of 60% sodium hydride and 5.4 ml of hexadecyl bromide is heated at 70° C. for 2 hours and then evaporated. The residue is purified by flash chromatography with an ethyl acetate:petroleum ether gradient to give 5.8 g of the desired compound as white crystals, mp. 46°-47° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05144045 |
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| Source dataset | uspto-grants-1992_09 |
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| ORD ID | ord-c086d78a72a64607b5a770999ce07443 |
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| Source note | uspto-grants-1992_09 |
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