HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1885494Generated: October 31, 2026
Acetic Anhydride → 5-acetamido-2-(N-benzyloxycarbonylamino)phenol
https://huagongshe.com/reaction/1885494
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 5-Amino-2-(benzyloxycarbonylamino)phenol | HCID 14745733 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-acetamido-2-(N-benzyloxycarbonylamino)phenol | HCID 14745734 | — |
Reaction Steps
0.6 mole (57 ml) of acetic anhydride is added dropwise to a solution of 0.6 mole (172 g) of 5-amino-2-(benzyloxycarbonylamino)phenol in 465 ml of dioxane heated to 70° C. After the reaction medium is cooled, the expected product precipitates. When recrystallized in 96° ethanol, it melts at 205° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05145483 |
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| Source dataset | uspto-grants-1992_09 |
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| ORD ID | ord-40b5c779409548e6a896d002da09348e |
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| Source note | uspto-grants-1992_09 |
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