Trifluoroacetic acid → HCID 19878787, compound

Participants

Reaction Steps

A mixture of 4.0 g. (10.7 mmole) ethyl 8-methylthio-2-(4-methylphenylsulphonyl)-octanoate, 5.35 ml of a 4 molar solution of trifluoroperacetic acid in trifluoroacetic acid and 7.5 ml. trifluoroacetic acid is stirred for 4 hours at 0° c. The solvent is then distilled off in a vacuum and the residue taken up in diethyl ether. This solution is washed with aqueous sodium hydrogen carbonate, dried and evaporated. The residue is chromatographed with a mixture of toluene and dioxan (5:1 v/v) on silica gel to give 3.2 g. (60% of theory) ethyl 8-methylsylphonyl-2-(4-methylphenylsulphonyl-octanoate in the form of a colourless oil.

Provenance & Evidence