2-Chlorophenol → 8-Chloro-4-(2-chlorophenoxy)quinoline

HRID 1885530노트

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HRID 1885530 반응식
Cl[C:2]1[C:11]2[C:6](=[C:7]([Cl:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[OH:20]>C(OCC)(=O)C>[Cl:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[CH:4][CH:3]=[C:2]2[O:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[Cl:13]

참가 물질

4

반응물 2

HCID 72452-ChlorophenolHCID 889734,8-Dichloroquinoline2회

생성물 1

HCID 1641768-Chloro-4-(2-chlorophenoxy)quinoline

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
160 °C

실험 절차

A mixture of 2.0 g of 4,8-dichloroquinoline and 2.6 g of 2-chlorophenol was heated to 160° C. and stirred. Progress of the reaction was monitored by TLC. When no 4,8-dichloroquinoline remained, the reaction mixture was diluted with ethyl acetate, and washed with base to remove most of the excess phenol. To remove phenol remaining after washing, the product was purified using HPLC. Fractions containing product were combined, and solvent was removed using reduced pressure. The oily product crystallized. Yield: 1.36 g (46%). M.P. 56°-58° C.

후처리

  1. washwashed with base
  2. customto remove most of the excess phenol
  3. customTo remove phenol remaining
  4. washafter washing
  5. customthe product was purified
  6. additionFractions containing product
  7. customsolvent was removed
  8. customThe oily product crystallized

출처 및 근거

ORD 기록
ord-417cddfe79ff4dbfb8309536995f387b
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05145843

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