HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 86744828, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Product | HCID 86744828 | HCID 86744828 | — |
| Product | HCID 86744829 | HCID 86744829 | — |
Reaction Steps
The product was dissolved in 50% trifluoroacetic acid in dichloromethane for 30 minutes, then evaporated, forming n-octyl Nim -benzyloxycarbonyl-L-histidyl-Ne -benzyloxycarbonyl-L-lysinate. This was dissolved in tetrahydrofuran, and isobutyl chloroformate, N-methylmorpholine and benzyloxycarbonylglycine were added to form n-octyl benzyloxycarbonylglycine-Nim -benzyloxycarbonyl-L-histidyl-Ne -benzyloxycarbonyl-L-lysinate. This was dissolved in glacial acetic acid and hydrogenated overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05145838 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-81bfacd9733b43948c8a6c9dc419c8fe |
| Source note | uspto-grants-1992_09 |