Triethylamine → HCID 53884514, compound

Participants

Reaction Steps

To a solution of 1.75 g (10 mmol) of the above 4-(cyanomethyl) methyl benzoate (6) in 10 mL of EtOH was added 1.14 g (10 mmol) of cysteamine hydrochloride and 1.4 mL (10 mmol) of triethylamine. The reaction mixture was refluxed for 24 h. and evaporated to dryness. The residue was dissolved in CH2Cl2 (50 mL), washed with water and dried over Na2SO4. Removal of the solvent gave crude 7, which was crystallized from EtOH. Yield 2.1 g (89%); mp 67°-68° C.; NMR (CDCl3), δ8.0 (m, 2H, aromatic), 7.4 (m, 2H, aromatic), 4.2 (t, 2H, CH2), 3.9 (s, 3H CH3), 3.85 (s, 2H, CH2); IR (Nujol), 720 (ester), 1620 (C=N) cm-1 ; MS (EI) calculated for (C12H13NO2S), 235.00; found, 235 (M+).

Provenance & Evidence