反应详情

To a solution of methyl 5-(4-acetylphenylsulfonyl)-4-(N,N-dipentylcarbamoyl)pentanoate (0.35 g) in methanol (15 ml) was added a 1N sodium hydroxide solution (1 ml). After stirring at room temperature for hours, the reaction mixture was concentrated in vacuo, acidified with a dilute hydrochloric acid, and extracted with chloroform. The organic layer was washed with water, dried over MgSO4, and evaporated at reduced pressure. The residue was recrystallized from dichloromethane-hexane to give 0.27 g of 5-(4-acetylphenylsulfonyl)-4-(N,N-dipentylcarbamoyl)pentanoic acid.

1. concentrationthe reaction mixture was concentrated in vacuo
2. extractionextracted with chloroform
3. washThe organic layer was washed with water
4. dry with materialdried over MgSO4
5. customevaporated at reduced pressure
6. customThe residue was recrystallized from dichloromethane-hexane