Sulfuric Acid → HCID 22116073, compound

Participants

Reaction Steps

Methyl 4-[1-(4-acetylaminophenyl)-2-pyrrolidon-4-yl]methoxybenzoate (1.70 g) is dissolved in methanol (30 ml) and thereto is added conc. sulfuric acid (0.24 ml). The mixture is stirred under refluxing for 23 hours. Subsequently, the reaction solution is concentrated under reduced pressure, and water and the neutralization amount of sodium hydrogen carbonate are added to the resulting residue. The precipitated crystal is collected by filtration and washed with water to give the desired product (1.47 g), m.p. 136°-138° C.

Provenance & Evidence