1-Bromo-2-methylpropane → HCID 22115923, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-[1-(4-hydroxyphenyl)-2-pyrrolidon-4-yl]methoxybenzoate (2.00 g), isobutyl bromide (2.58 ml) and potassium carbonate (3.24 g) are dissolved and suspended in dimethylformamide (20 ml) and the mixture is heated with stirring at 80° C. for 24 hours. The solvent is distilled off under reduced pressure and water is added to the resulting residue. The resulting precipitate is collected by filtration and recrystallized from about 20% aqueous methanol to give the desired product (2.11 g}, m.p. 117.5°-118.5° C.

Provenance & Evidence