Benzoyl Peroxide → HCID 22116003, compound

Participants

Reaction Steps

Methyl 4-[1-(4-tolyl)-2-pyrrolidon-4-yl]methoxybenzoate (3.00 g) and N-bromosuccinimide (1.81 g) are suspended in carbon tetrachloride (50 ml), and thereto is added benzoyl peroxide (0.21 g) and the mixture is stirred under refluxing for 5 hours. The reaction mixture is filtered and the filtrate is concentrated under reduced pressure. The residue is dissolved in ethyl acetate (60 ml), washed successively with aqueous sodium hydrogen carbonate solution and water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting oily product is subjected to silica gel column chromatography and eluted with a mixed solvent of chloroform/n-hexane [1:1 (v/v)]to give the desired product (2.10 g).

Provenance & Evidence