Isobutylene oxide → HCID 22116058, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-[1-[4-hydroxyphenyl)-2-pyrrolidon-4-yl]methoxybenzoate (2.00 g) and potassium carbonate (1.62 g) are dissolved and suspended in dimethylformamide (20 ml) and thereto is added isobutylene oxide (1.06 ml). The mixture is stirred at 80° C. for 17 hours and thereto is added isobutylene oxide (1.06 ml), and the mixture is further heated with stirring for 5 hours. The reaction mixture is concentrated under reduced pressure and thereto is added water. The insoluble material is collected by filtration, washed with water and recrystallized from about 30% aqueous methanol to give the desired product (2.15 g), m.p. 89.5°-90.5° C.

Provenance & Evidence