Tetrahydrofuran → HCID 54334725, compound

Participants

Reaction Steps

To a solution of the silylether (58 mg, 0.1 mmole) in tetrahydrofuran (2 ml) was added tetra-n-butylammonium fluoride trihydrate (50 mg, 0.15 mmole). The mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure. The residue was dissolved in methylene chloride, washed with water and dried over sodium sulfate. Filtration and concentration under reduced pressure afforded an oil. Flash chromatography on silicagel and elution with a 2:8 mixture of ethyl acetate and hexane afforded the expected alcohol as an oil (21 mg, 68%).

Provenance & Evidence