HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 2-Methyl-1-(4-morpholinophenyl)-2-morpholinopropan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(4-Fluorphenyl)-2-methyl-2-morpholino-1-propanone | HCID 15405305 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Methyl-1-(4-morpholinophenyl)-2-morpholinopropan-1-one | HCID 19879493 | — |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
15.08 g (0.06 mol) of 1-(4-fluorophenyl)-2-methyl-2-morpholinopropan-1-one and 5.23 g (0.06 mol) of morpholine are dissolved in 25 ml of dimethyl sulfoxide, and the solution is heated to 160° C. together with 8.3 g (0.05 mol) of potassium carbonate. After 18 hours of stirring at about 160° C. the suspension is cooled down and is poured onto an ice-water mixture. The crystals are filtered off, are washed with water and are recrystallised from ethanol. Melting point 114°-116° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05145885 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-022f5ef7ef204c7f823cc083e791547a |
| Source note | uspto-grants-1992_09 |