HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-Methyl-1-[4-(4-methylpiperazino)phenyl]-2-(4-methylpiperazino)-propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 1-(4-Fluorophenyl)-2-methyl-2-(4-methylpiperazino)-propan-1-one | HCID 19879482 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Methyl-1-[4-(4-methylpiperazino)phenyl]-2-(4-methylpiperazino)-propan-1-one | HCID 19879431 | — |
Reaction Conditions
| Temperature | 115 °C |
|---|
Reaction Steps
13.2 g (0.05 mol) of 1-(4-fluorophenyl)-2-methyl-2-(4-methylpiperazino)-propan-1-one and 6.5 g (0.065 mol) of 1-methylpiperazine are dissolved in 20 ml of dimethyl sulfoxide, and the solution is heated to about 115° C. together with 6.9 g (0.05 mol) of potassium carbonate. After 15 hours of stirring at about 115° C. the suspension is cooled down and is poured at about 60° C. onto ice. The crystals are filtered off and are recrystallised twice from ethyl acetate. Melting point 133°-136° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05145885 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-91819fbd1f0c478c9301ea2d7b1ea326 |
| Source note | uspto-grants-1992_09 |