Potassium Hydroxide → 1-Cyclohexyloxy-2,2,6,6-tetramethyl-piperidin-4-ol

HRID 1885667Notes

Reaction equation

HRID 1885667 reaction equation
C([O:9][CH:10]1[CH2:15][C:14]([CH3:17])([CH3:16])[N:13]([O:18][CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[C:12]([CH3:26])([CH3:25])[CH2:11]1)(=O)C1C=CC=CC=1.[OH-].[K+]>CO>[CH:19]1([O:18][N:13]2[C:12]([CH3:25])([CH3:26])[CH2:11][CH:10]([OH:9])[CH2:15][C:14]2([CH3:17])[CH3:16])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 233720981-Cyclohexyloxy-4-benzoyloxy-2,2,6,6-tetramethylpiperidine

Product 1

HCID 113228111-Cyclohexyloxy-2,2,6,6-tetramethyl-piperidin-4-ol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The ester obtained in Example 2A is hydrolyzed using potassium hydroxide in aqueous methanol to give the title compound as a white solid melting at 74°-78° C.

Sources & evidence

ORD record
ord-24f0b3a1684143e49b1447bc6d2cb457
Source dataset
uspto-grants-1992_09
Patent number
US05145893

Reaction notes

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