HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → Methyl 2-(2-[4-fluorophenyl]ethyl)phenylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Phenylacetonitrile | HCID 8794 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Reactant | Phenylacetate | HCID 4409936 | — |
| Reactant | {[2-(Methoxycarbonyl)phenyl]methyl}(triphenyl)phosphanium bromide | HCID 10743695 | — |
| Reactant | Methyl 2-[2-(2-furyl)ethyl]phenylacetate | HCID 19879669 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-(2-[4-fluorophenyl]ethyl)phenylacetate | HCID 19879670 | — |
Reaction Steps
Methyl 2-(2-[4-fluorophenyl]ethyl)phenylacetate was prepared from 4-fluorobenzaldehyde and (o-methoxycarbonylbenzyl)triphenylphosphonium bromide by a route similar to that described in Example 3 for the preparation of methyl 2-[2-(2-furyl)ethyl]phenylacetate. In this instance, the benzyl chloride was converted into the phenylacetate by treatment with potassium cyanide in DMSO and, then, methanolysis of the resulting phenylacetonitrile with sulphuric acid in methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05145954 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-51a733eb0d084f3f86d134e975174bbe |
| Source note | uspto-grants-1992_09 |