Hydrochloric Acid → HCID 135714911, compound

Participants

Reaction Steps

A stirred solution of 4-methylthio-2-(2-propoxybenzamido)benzamide (0.85 g) and pyridine (1 ml) in 2 Normal aqueous sodium hydroxide was heated under reflux for 2 hours. The cooled reaction mixture was acidified with concentrated hydrochloric acid and the resultant mixture was extracted with chloroform (3×25 ml). The combined extracts were washed with water and then brine, dried (magnesium sulphate) and evaporated under reduced pressure to yield a solid which was recrystallised from ethanol to yield the title compound, 0.61 g, m.p. 156.5°-158.5° C.

Provenance & Evidence