Sodium Acetate →

HRID 1885861Notes

Reaction equation

HRID 1885861 reaction equation
[N:1]1([CH2:7][CH:8](Cl)[CH2:9][ClH:10][C:11](=[N:18][OH:19])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:21]([O-:24])(=[O:23])[CH3:22].[Na+]>C(O)C.O>[N:1]1([CH2:7][CH:8]([O:24][C:21](=[O:23])[CH3:22])[CH2:9][ClH:10][C:11](=[N:18][OH:19])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 517045Sodium Acetate

Product 0

No Product data yet.

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

3.0 g (9.49 mmoles) of O-(3-piperidino-2-chloro-1-propyl)-benzhydroximic acid chloride were dissolved in 10 ml of ethanol, under stirring 0.86 g (1.05·10-2 moles) of sodium acetate in 15 ml of water were added and the mixture was stirred for 3 hours at 50° C. The reaction mixture was evaporated in vacuo and the residue was extracted with benzene. The benzene extract was dried over sodium sulfate and evaporated, thus providing 2.12 g of oily O-(3-piperidino-2-acetoxy-1-propyl)-benzhydroximic acid chloride. The ester thus obtained was dissolved in 20 ml of ethanol followed by the addition of 20 ml of water. 0.25 g of NaOH in 20 ml of water were added to the mixture and stirred at 40° C. for one hour, extracted with benzene, the benzene extract was dried with sodium sulfate and evaporated. From the residue salt was formed according to the method in process a). Yield 90%. The quality of the product was identical with that of process a).

Workup

  1. additionwere added
  2. customThe reaction mixture was evaporated in vacuo
  3. extractionthe residue was extracted with benzene
  4. extractionThe benzene extract
  5. dry with materialwas dried over sodium sulfate
  6. customevaporated

Sources & evidence

ORD record
ord-a73c3e1326644fe78bf3388955900ede
Source dataset
uspto-grants-1992_09
Patent number
US05147879

Reaction notes

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