HCID 14988435, compound → HCID 14988437, compound

HRID 1885869Notes

Reaction equation

HRID 1885869 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[S:9][CH2:8][CH2:7][NH:6][C:5]2=[C:10]([C:12]([OH:14])=[O:13])[CH:11]=1.I([O-])(=O)(=O)=[O:16].[Na+]>CO.O>[Br:1][C:2]1[CH:3]=[C:4]2[S:9](=[O:16])[CH2:8][CH2:7][NH:6][C:5]2=[C:10]([C:12]([OH:14])=[O:13])[CH:11]=1

Participants

5

Reactant 2

HCID 14988435HCID 14988435, compoundHCID 23667635Sodium periodate

Product 1

HCID 14988437HCID 14988437, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 7-bromo-3,4-dihydro-2H-1,4-benzothiazine-5-carboxylic acid (500 mg) in methanol 80 ml) was added 0.05M sodium metaperiodate solution (40 ml) The mixture was stirred for 5 hours at room temperature, then diluted with water (500 ml) and concentrated until crystals began to separate. The crystals were collected and dried to give the title compound (300 mg, 57.5% which was recrystallized from ethanol to give pale yellow crystals, mp 254°-255° C. (decompd.).

Workup

  1. concentrationconcentrated until crystals
  2. customto separate
  3. customThe crystals were collected
  4. customdried

Sources & evidence

ORD record
ord-fe9cb8377fb64f4ea04db9ab6e930f9c
Source dataset
uspto-grants-1992_09
Patent number
US05147874

Reaction notes

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