Methanesulfonyl chloride → HCID 14988477, compound

HRID 1885871Notes

Reaction equation

HRID 1885871 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]([O:14]C)=[O:13])[CH:11]=1)[NH:8][CH2:7][CH2:6][CH2:5]2.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>>[CH3:16][S:17]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]([OH:14])=[O:13])[CH:11]=1)[NH:8][CH2:7][CH2:6][CH2:5]2)(=[O:19])=[O:18]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 15106991HCID 15106991, compound

Product 1

HCID 14988477HCID 14988477, compoundYield 79.9%

Procedure

The title compound was prepared (79.9% yield) from methyl 6-amino-1,2,3,4-tetrahydroquinoline-8-carboxylate by the same procedure as in Example 32 by using methanesulfonyl chloride instead of p-toluenesulfonyl chloride. This compound was recrystallized form ethanol to give yellow crystals, mp 244° C.

Workup

  1. customThis compound was recrystallized form ethanol
  2. customto give yellow crystals, mp 244° C.

Sources & evidence

ORD record
ord-579e5e2836044129b8a8fb2ffa2a3818
Source dataset
uspto-grants-1992_09
Patent number
US05147874

Reaction notes

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