HuagongsheHuagongshe Chemistry Print Report · For research reference only
Maleic Acid → 4-Methylamino-2-(4-phenylpiperidino)pyrimidine maleate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Maleic Acid | HCID 444266 | — |
| Reactant | N-Methyl-2-(4-phenylpiperidin-1-yl)pyrimidin-4-amine | HCID 15229206 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Methylamino-2-(4-phenylpiperidino)pyrimidine maleate | HCID 67759630 | 87.2% |
Reaction Steps
A solution of 0.43 g (3.73 mmoles) of maleic acid in 10 ml of methanol was added to a solution of 1.0 g (3.73 mmoles) of 4-methylamino-2-(4-phenylpiperidino)pyrimidine in 10 ml of methanol, and the mixture was stirred at room temperature for 1 hour. The mixed solution was concentrated under reduced pressure and washed with ether to give 1.25 g (yield 87 %) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05147876 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-d340edba496e464c9e3001e81a15a68f |
| Source note | uspto-grants-1992_09 |