Methanol → 1-amino-3-propyl-5-hydroxyhexahydrocyclopenta[d]imidazole-2(1H)-one

Participants

Reaction Conditions

Reaction Steps

The compound of step (f) (7.0 g) was added to a solution of methanol (280 ml) and acetic acid (2.25 ml) containing 10% Pd on carbon (2.5 g) and the resulting mixture stirred at 15° C. under an atmosphere of hydrogen for 3 days. The catalyst was removed by filtration through Celite and concentration of the filtrate in vacuo gave the desired product as an oil (5.0 g).

Provenance & Evidence