反应详情

温度

15 °C

A solution of the compound of step (g) (5.0 g) and 2-acetoxy-2-cyclohexylacetaldehyde (Ross et al, J. Med. Chem., 22, 412 (1979), 6.0 g) in methanol (175 ml) containing sodium acetate (3.64 g) was stirred at 15° C. under a nitrogen atmosphere for 16 hours. The alcohol was removed in vacuo and water (100 ml) and chloroform (100 ml) added. The organic phase was separated and washed with brine (100 ml), then dried over anhy. sodium sulphate. Filtration and concentration of the filtrate in vacuo gave a yellow oil (10.8 g).

1. customThe alcohol was removed in vacuo and water (100 ml) and chloroform (100 ml)
2. additionadded
3. customThe organic phase was separated
4. washwashed with brine (100 ml)
5. customdried over anhy
6. filtrationFiltration and concentration of the filtrate in vacuo