Potassium Carbonate → HCID 19878308, compound

Participants

Reaction Steps

A 7 g portion of the compound of Example 1 was reacted with 6.6 g of 2-chloroethyl-bis(isopropyl)amine hydrochloride in the presence of 12.2 g of potassium carbonate in 75 ml of methyl ethyl ketone. The mixture was stirred under reflux for 72 hours, and was then worked up as described in Example 5. The impure product was chromatographed over silica gel with a gradient solvent proceeding from toluene to 9:1 toluene:ethyl acetate. Concentration of the product-containing fractions gave 4.16 g of the desired product, m.p. 106°-115° C.

Provenance & Evidence