Sodium Hydroxide → HCID 86746146, compound

Participants

Reaction Steps

In 500 ml of methanol was dissolved 44 g of methyl N-pivaloyl-L-valine-6-aminohexanoate followed by addition of 150 ml of 1N sodium hydroxide and the mixture was stirred at room temperature for 45 minutes. The ethanol was then evaporated off and 1N HCl and, then, ether were added to the residue. The mixture was shaken to extract the reaction product into the ether. The water layer was removed and the ether layer was dried over magnesium sulfate anhydride and concentrated to dryness under reduced pressure to give 35 g (0.112 mol) of the desired compound.

Provenance & Evidence