6-(Pyrimidin-5-YL)hex-5-YN-1-OL → 6-(Pyrimidin-5-yl)hexan-1-ol

HRID 1886013Notes

Reaction equation

HRID 1886013 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1>C(O)C.[Pd]>[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1

Participants

4

Reactant 1

HCID 139997526-(Pyrimidin-5-YL)hex-5-YN-1-OL

Product 1

HCID 135575446-(Pyrimidin-5-yl)hexan-1-olYield 93.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

A solution of 6-(5-pyrimidinyl)-5-hexynol (3.52 g) in ethanol (20 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (1 g) in ethanol (130 ml) and hydrogenated at room temperature and pressure. The mixture was filtered through hyflo and the filtrate evaporated in vacuo to give the title compound as a pale yellow oil (3.38 g).

Workup

  1. filtrationThe mixture was filtered through hyflo
  2. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-05cc9a89d0ca4e758c1a8d4f93b9f13c
Source dataset
uspto-grants-1992_09
Patent number
US05149698

Reaction notes

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