HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 19876826, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-(2-aminoethyl)acetamide | HCID 66082 | — |
| Reactant | 1H-benzimidazole, 1-methyl-2-(methylsulfonyl)- | HCID 640715 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 19876826 | HCID 19876826 | 30% |
Reaction Steps
A mixture of 2-methylsulfonyl-1-methyl-1H-benzimidazole (7.0 g, 0.033 mol) and N-acetylethylenediamine (17.0 g, 0.167 mol) was heated at 120°-125° C. for 8 hours. The mixture was cooled, diluted with H2O, made basic (pH8) with 2.5N NaOH, and filtered. The filtrate was extracted with EtOAc, and the combined extracts were washed with brine, dried, and concentrated to give a yellow solid 2.3 g (30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05149700 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-30c1f321743f4c65893aa24b4c8df49f |
| Source note | uspto-grants-1992_09 |