反应详情

温度

0 °C

According to the procedure of A. T. James, et al., J. Chem. Soc., 1515, (1950), to cooled (0° C.), stirred nitric acid (300 mL) was added all at once 2-hydroxy-1H-benzimidazole. After 1 minute a yellow precipitate had formed. The cooling bath was removed and stirring was continued for 10 minutes. The mixture was poured onto ice, and the off-white solid was collected by filtration and dried under vacuum at 60° C. to give 25.1 g (94%) of product m.p. >300° C.

1. customAfter 1 minute a yellow precipitate had formed
2. customThe cooling bath was removed
3. additionThe mixture was poured onto ice
4. filtrationthe off-white solid was collected by filtration
5. customdried under vacuum at 60° C.