Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 2-(2-(Methylamino)-1H-benzo[d]imidazol-1-yl)ethan-1-ol | HCID 6618973 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 15142708 | HCID 15142708 | 71% |
Reaction Steps
To a cooled (0° C.), stirred mixture of 1-(2-hydroxyethyl)-2-methylamino-1H-benzimidazole (8.05 g, 42.12 mmol), Et3N (4.26 g, 42.12 mmol), and CH2Cl2 (85 mL) was added a solution of MsCl (4.83 g, 42.12 mmol) in CH2Cl2 (10 mL). After 2 hours, H2O was added and the layers were separated. The aqueous phase was extracted with CH2Cl2. The combined extracts were washed with brine, dried, and concentrated to give 8.00 g (71%) of a white solid m.p. 48°-50° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05149700 |
|---|
| Source dataset | uspto-grants-1992_09 |
|---|
| ORD ID | ord-5e65558973f14b0182590fdf9e0088f7 |
|---|
| Source note | uspto-grants-1992_09 |
|---|
