Thionyl Chloride → HCID 19876905, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (0° C.) flask containing [(2-fluorophenyl)(3-fluorophenyl)phenyl]carbinol (20 g, 67.5 mmol) (obtained in example 1) was slowly added thionyl chloride (12.82 g, 108 mmol) with vigorous stirring. Once the reaction had been initiated (gas evolution), the rest of the thionyl chloride was added at once and the reaction mixture heated to reflux for 4 h. Volatiles were removed in vacuo and the remaining traces of thionyl chloride were removed by azeotropic evaporation with toluene (2×). The resulting residue was dissolved in petroleum ether and precipitated by cooling to -20° C. The solid was filtered and dried to afford the title compound as a slightly cream-colored solid (18.1 g, 85%).

Provenance & Evidence