Toluene → HCID 19876841, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product of Step 2 (25 g, 84.5 mmol) in toluene (1.2 L) at 60° C. was added AlCl3 (45 g, 338 mmol) in portions. The mixture was stirred at 60° C. for 14 hrs. NH4Cl solution was added and the mixture was extracted with EtOAc. The crude concentrated extract was treated with excess CH2N2 in Et2O. Chromatography of the resulting product on silica gel (eluted with 30% EtOAc/hexane) gave 17.5 g (70%) of the title compound.

Provenance & Evidence