Potassium Carbonate → HCID 19876843, compound

Participants

Reaction Steps

A mixture of the product of Step 3 (17.5 g, 59 mmol), 2-bromomethyl-7-chloroquinoline (16.65 g, 65 mmol) and K2CO3 (8.97 g, 65 mmol) in acetone (200 ml) was refluxed for 14 hrs. The mixture was filtered and the filtrate was concentrated in vacuo. Chromatography of the resulting crude product on silica gel (eluted with 30% EtOAc/hexane) gave 21.15 g(80%) of the title compound.

Provenance & Evidence