Acetic Acid → HCID 19876845, compound

Participants

Reaction Steps

To a solution of the product of Step 6 (131 mg, 0.229 mmol) in THF/MeOH (1.5 ml, 1:2) was added 1M K2CO3 (0.687 ml). The mixture was stirred at room temperature for 20 hrs. NH4Cl solution was added and the pH was adjusted to 5 with HOAc. Extraction with EtOAc followed by chromatography of the crude product on silicic acid (eluted with 30% EtOAc/hexane) gave 100 mg of the title compounds.

Provenance & Evidence